Lack of racial and ethnic diversity in lung cancer cell lines contributes to lung cancer health disparities.

ABSTRACT: Lung cancer is the leading cause of cancer death in the United States and worldwide, and a major source of cancer health disparities. Lung cancer cell lines provide key in vitro models for molecular studies of lung cancer development and progression, and for pre-clinical drug testing. To ensure health equity, it is imperative that cell lines representing different lung cancer histological types, carrying different cancer driver genes, and representing different genders, races, and ethnicities should be available. This is particularly relevant for cell lines from Black men, who experience the highest lung cancer mortality in the United States. Here, we undertook a review of the available lung cancer cell lines and their racial and ethnic origin. We noted a marked imbalance in the ava

SUBMITTER: Leon C 

PROVIDER: S-EPMC10651223 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature