Overcoming phenotypic switching: targeting protein-protein interactions in cancer.

ABSTRACT: Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative pathogenic signals and are particularly significant in cancer. In recent years, PPIs have emerged as promising targets for rational drug design, primarily because their high specificity facilitates targeting of disease-related signaling pathways. However, obstacles exist at the molecular level that arise from the properties of the interaction interfaces and the propensity of small molecule drugs to interact with more than one cleft surface. The difficulty in identifying small molecules that act as activators or inhibitors to counteract the biological effects of mutations raises issues that have

SUBMITTER: Ladias C 

PROVIDER: S-EPMC10651353 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature