Applying systems thinking to unravel the mechanisms underlying orthostatic hypotension related fall risk.

ABSTRACT: Orthostatic hypotension (OH) is an established and common cardiovascular risk factor for falls. An in-depth understanding of the various interacting pathophysiological pathways contributing to OH-related falls is essential to guide improvements in diagnostic and treatment opportunities. We applied systems thinking to multidisciplinary map out causal mechanisms and risk factors. For this, we used group model building (GMB) to develop a causal loop diagram (CLD). The GMB was based on the input of experts from multiple domains related to OH and falls and all proposed mechanisms were supported by scientific literature. Our CLD is a conceptual representation of factors involved in OH-related falls, and their interrelatedness. Network analysis and feedback loops were applied to analyze and inter

SUBMITTER: Wang L 

PROVIDER: S-EPMC10651607 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature