Longitudinal lipidomic signatures of all-cause and CVD mortality in American Indians: findings from the Strong Heart Study.

ABSTRACT: Dyslipidemia is an independent and modifiable risk factor for aging and age-related disorders. Routine lipid panel cannot capture all individual lipid species in blood (i.e., blood lipidome). To date, a comprehensive assessment of the blood lipidome associated with mortality is lacking in large-scale community-dwelling individuals, especially in a longitudinal setting. Using liquid chromatograph-mass spectrometry, we repeatedly measured individual lipid species in 3,821 plasma samples collected at two visits (~ 5.5 years apart) from 1,930 unique American Indians in the Strong Heart Family Study. We first identified baseline lipids associated with risks for all-cause mortality and CVD mortality (mean follow-up period: 17.8 years) in American Indians, followed by replication of top hits in E

SUBMITTER: Miao G 

PROVIDER: S-EPMC10651623 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature