Model-informed precision dosing of vancomycin for rapid achievement of target area under the concentration-time curve: A simulation study.

ABSTRACT: In this study, we aimed to evaluate limited sampling strategies for achieving the therapeutic ranges of the area under the concentration-time curve (AUC) of vancomycin on the first and second day (AUC_0-24 , AUC_24-48 , respectively) of therapy. A virtual population of 1000 individuals was created using a population pharmacokinetic (PopPK) model, which was validated and incorporated into our model-informed precision dosing tool. The results were evaluated using six additional PopPK models selected based on a study design of prospective or retrospective data collection with sufficient concentrations. Bayesian forecasting was performed to evaluate the probability of achieving the therapeutic range of AUC, defined as a ratio of estimated/reference AUC within 0.8-1.2. The B

SUBMITTER: Oda K 

PROVIDER: S-EPMC10651648 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature