Valproic acid treatment attenuates cisplatin-induced kidney injury by suppressing proximal tubular cell damage.

ABSTRACT: Cisplatin treatment is effective against several types of carcinomas. However, it frequently leads to kidney injury, which warrants effective prevention methods. Sodium valproic acid is a prophylactic drug candidate with a high potential for clinical application against cisplatin-induced kidney injury. Therefore, in this study, we aimed to elucidate the mechanism underlying the prophylactic effect of valproic acid on cisplatin-induced kidney injury in a mouse model and HK2 and PODO cells with cisplatin-induced toxicity. In the mouse model of cisplatin-induced kidney injury, various renal function parameters and tubular damage scores were worsened by cisplatin, but they were significantly improved upon combination with valproic acid. No difference was observed in cisplatin accumulation betw

SUBMITTER: Yoshioka T 

PROVIDER: S-EPMC10651653 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature