Serum HMGB1 is a biomarker for acute myocardial infarction with or without heart failure.

ABSTRACT: This study measured serum high mobility group box 1 (HMGB1) levels in patients with acute myocardial infarction (AMI) and/or heart failure (HF) and evaluated their relationship with peripheral inflammatory biomarkers and cardiac biomarkers, which have not been reported before. Of the patients, 55 had AMI without HF (AMI^-HF ), 42 had AMI with HF (AMI^+HF ), and 60 had HF without AMI (HF^-AMI ) compared with 50 healthy controls. Blood samples were collected to assess serum HMGB1 levels and blood test-related inflammatory biomarkers (e.g., erythrocyte sedimentation rate [ESR], hs-CRP, uric acid, and white blood cell count) and cardiac biomarkers (e.g., MYO, cTnI, CKMB, CK, NT-proBNP, LDH, aspartate aminotransferase [AST], and alanine aminotransferase [ALT]). Com

SUBMITTER: Wahid A 

PROVIDER: S-EPMC10651663 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature