Sex differences in skeletal muscle-aging trajectory: same processes, but with a different ranking.

ABSTRACT: Sex differences in muscle aging are poorly understood, but could be crucial for the optimization of sarcopenia-related interventions. To gain insight into potential sex differences in muscle aging, we recruited young (23 ± 2 years, 13 males and 13 females) and old (80 ± 3.5 years, 28 males and 26 females) participants. Males and females in both groups were highly matched, and vastus lateralis muscle parameters of old versus young participants were compared for each sex separately, focusing on gene expression. The overall gene expression profiles separated the sexes, but similar gene expression patterns separated old from young participants in males and females. Genes were indeed regulated in the same direction in both sexes during aging; however, the magnitude of differential expression wa

SUBMITTER: de Jong JCBC 

PROVIDER: S-EPMC10651666 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature