Ontology highlight
ABSTRACT:
SUBMITTER: Romerio A
PROVIDER: S-EPMC10651716 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Romerio Alessio A Peri Francesco F
Frontiers in chemistry 20231102
We developed synthetic glycophospholipids based on a glucosamine core (FP compounds) with potent and selective activity in stimulating Toll-Like Receptor 4 (TLR4) as agonists. These compounds have activity and toxicity profiles similar to the clinically approved adjuvant monophosphoryl lipid A (MPLA), included in several vaccine formulations, and are now in the preclinical phase of development as vaccine adjuvants in collaboration with Croda International PLC. FP compound synthesis is shorter an ...[more]