Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.

ABSTRACT: Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: "Some College" (yes/no, for any education beyond high school) and "Graduated College" (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10^-8) and suggestive (p < 1 × 10^-6) variants were identified in

SUBMITTER: de las Fuentes L 

PROVIDER: S-EPMC10651736 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature