Survival nomogram for medulloblastoma and multi-center external validation cohort.

ABSTRACT: Background: Medulloblastoma (MB) is a highly malignant neuroepithelial tumor occurring in the central nervous system. The objective of this study was to establish an effective prognostic nomogram to predict the overall survival (OS) of MB patients. Materials and methods: The nomogram was developed using data from a retrospective cohort of 280 medulloblastoma patients (aged 3-18 years) identified from Beijing Tiantan Hospital between 2016 and 2021 as the training cohort. To validate the performance of the nomogram, collaborations were formed with eight leading pediatric oncology centers across different regions of China. A total of 162 medulloblastoma patients meeting the inclusion criteria were enrolled from these collaborating centers. Cox regression analysis, best subsets r

SUBMITTER: Li X 

PROVIDER: S-EPMC10651750 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature