Ontology highlight
ABSTRACT:
SUBMITTER: Panelli P
PROVIDER: S-EPMC10651788 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Panelli Patrizio P De Santis Elisabetta E Colucci Mattia M Tamiro Francesco F Sansico Francesca F Miroballo Mattia M Murgo Emanuele E Padovano Costanzo C Gusscott Sam S Ciavarella Michele M Chavez Elizabeth A EA Bianchi Fabrizio F Rossi Giovanni G Carella Angelo M AM Steidl Christian C Weng Andrew P AP Giambra Vincenzo V
Blood 20230301 13
T-cell acute lymphoblastic leukemia (T-ALL) is a T-cell malignancy characterized by cell subsets and enriched with leukemia-initiating cells (LICs). β-Catenin modulates LIC activity in T-ALL. However, its role in maintaining established leukemia stem cells remains largely unknown. To identify functionally relevant protein interactions of β-catenin in T-ALL, we performed coimmunoprecipitation followed by liquid chromatography-mass spectrometry. Here, we report that a noncanonical functional inter ...[more]