Mechanistic Insights of Copper Catalyzed Trifluoromethyl Aziridine Opening: Regioselective and Stereospecific Aryl Grignard Addition.

ABSTRACT: The copper catalyzed regioselective and stereospecific opening of CF₃-aziridines is reported. This method focuses on the synthesis of α-CF₃-β-arylethylamines, which can be potential key intermediates in the synthesis of synthetic analogues and biologically active molecules. Density functional theory calculations reveal the nature of the active copper species and the role of the LiClMgX₂ (X = Cl or I) as a Lewis acid. Further, the computed mechanism accounts for the high regioselectivity of this transformation.

SUBMITTER: Lee M 

PROVIDER: S-EPMC10651793 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature