Preserved autophagy in cognitively intact non-demented individuals with Alzheimer's neuropathology.

ABSTRACT:

Introduction

Growing evidence supports that dysfunctional autophagy, the major cell mechanism responsible for removing protein aggregates and a route of clearance for Tau in healthy neurons, is a major finding in demented Alzheimer's disease (AD) patients. However, the association of autophagy with maintenance of cognitive integrity in resilient individuals who have AD neuropathology but remain non-demented (NDAN) has not been evaluated.

Methods

Using post mortem brain samples from age-matched healthy control, AD, and NDAN subjects, we evaluated autophagy in relation to Tau pathology using Western blot, immunofluorescence and RNA-seq.

Results

Compared to AD patients, NDAN subjects had preserved autophagy and reduced tauopathy. Furthermore, expression of autophagy gene

SUBMITTER: Tumurbaatar B 

PROVIDER: S-EPMC10651802 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature