Proteomic basis of mortality resilience mediated by FOXO3 longevity genotype.

ABSTRACT: FOXO3 is a ubiquitous transcription factor expressed in response to cellular stress caused by nutrient deprivation, inflammatory cytokines, reactive oxygen species, radiation, hypoxia, and other factors. We showed previously that the association of inherited FOXO3 variants with longevity was the result of partial protection against mortality risk posed by aging-related life-long stressors, particularly cardiometabolic disease. We then referred to the longevity-associated genotypes as conferring "mortality resilience." Serum proteins whose levels change with aging and are associated with mortality risk may be considered as "stress proteins." They may serve as indirect measures of life-long stress. Our aims were to (1) identify stress proteins that increase with aging and are associated with

SUBMITTER: Donlon TA 

PROVIDER: S-EPMC10651822 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature