Gut microbiota diversity before allogeneic hematopoietic stem cell transplantation as a predictor of mortality in children.

ABSTRACT: The correlation existing between gut microbiota diversity and survival after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has so far been studied in adults. Pediatric studies question whether this association applies to children as well. Stool samples from a multicenter cohort of 90 pediatric allo-HSCT recipients were analyzed using 16S ribosomal RNA amplicon sequencing to profile the gut microbiota and estimate diversity with the Shannon index. A global-to-local networking approach was used to characterize the ecological structure of the gut microbiota. Patients were stratified into higher- and lower-diversity groups at 2 time points: before transplantation and at neutrophil engraftment. The higher-diversity group before transplantation exhibited a higher probability of

SUBMITTER: Masetti R 

PROVIDER: S-EPMC10651870 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature