Metabolic associated fatty liver disease and sarcopenia additively increase mortality: a real-world study.

ABSTRACT:

Background and aims

Sarcopenia is associated with worse prognosis for non-alcoholic fatty liver disease (NAFLD). However, disease progression in the MAFLD-related sarcopenia is largely unknown. We aimed to clarify the relationship between MAFLD and/or sarcopenia with mortality and liver fibrosis in the real world.

Methods

A total of 13,692 individuals were selected from the third National Health and Nutrition Examination Surveys and linked mortality until December 2019. MAFLD is diagnosed based on a radiologically diagnosed hepatic steatosis and the presence of any one of the following three conditions: overweight/obesity, diabetes mellitus (DM), or metabolic dysregulation. Sarcopenia is defined by weight-adjusted skeletal muscle mass.

Results

The mean age was 43.7 ± 

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC10651884 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature