A supramolecular system mimicking the infection process of an enveloped virus through membrane fusion.

ABSTRACT: Membrane fusion is an essential step for the entry of enveloped viruses, such as human immunodeficiency virus and influenza virus, into the host cell, often triggered by the binding of membrane proteins on the viral envelope to host cell membrane. Recently, external stimuli was shown to trigger membrane fusion in an artificial system. Direct observation of artificial membrane fusion using a giant unilamellar vesicle (GUV), which is similar in size to a cell, is useful as a biological model system. However, there are no model systems for studying membrane fusion of enveloped viruses with host cells. Here, we report a supramolecular model system for viral entry into a GUV or cell through membrane fusion. The system was constructed by complexing a cationic lipid bilayer on an anionic artifici

SUBMITTER: Furukawa H 

PROVIDER: S-EPMC10651892 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature