Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets.

ABSTRACT: Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell subsets, which protects from immunopathogenesis, but also hampers the development of effective anti-parasitic immunity. Understanding malaria induced tolerogenic responses in specific cell subsets may inform development of strategies to boost protective immunity during drug treatment and vaccination. Here, we analyse the immune landscape with single cell RNA sequencing during P. falciparum malaria. We identify cell type specific responses in sub-clustered major immune cell types. Malaria is associated with an increase in immunosuppressive monocytes, alongside NK and γδ T cells which up-regulate tolerogenic markers. IL-10-producing Tr1 CD4 T cells and IL-10-producing regulatory B cells are also induced. Typ

SUBMITTER: Dooley NL 

PROVIDER: S-EPMC10651914 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature