Altered large-scale individual-based morphological brain network in spinocerebellar ataxia type 3.

ABSTRACT:

Background

Accumulating evidences indicate regional gray matter (GM) morphology atrophy in spinocerebellar ataxia type 3 (SCA3); however, whether large-scale morphological brain networks (MBNs) undergo widespread reorganization in these patients remains unclear.

Objective

To investigate the topological organization of large-scale individual-based MBNs in SCA3 patients.

Methods

The individual-based MBNs were constructed based on the inter-regional morphological similarity of GM regions. Graph theoretical analysis was taken to assess GM structural connectivity in 76 symptomatic SCA3, 24 pre-symptomatic SCA3, and 54 healthy normal controls (NCs). Topological parameters of the resulting graphs and network-based statistics analysis were compared among symptomatic SCA3, pre

SUBMITTER: Su S 

PROVIDER: S-EPMC10651944 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature