Metabolomics of cerebrospinal fluid reveals prognostic biomarkers in pediatric status epilepticus.

ABSTRACT:

Aims

Status epilepticus (SE) is the most common neurological emergency in pediatric patients. This study aimed to screen for prognostic biomarkers of SE in the cerebrospinal fluid (CSF) using metabolomics.

Methods

Ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-MS) was conducted to identify prognostic biomarkers in CSF metabolomics by comparing the poor outcome group (N = 13) with the good outcome group (N = 15) of children with SE. Differentially expressed metabolites were identified using Mann-Whitney U test corrected by Benjamini-Hochberg and partial least squares discriminant analysis (PLS-DA).

Results

The PLS-DA model identified and validated significant metabolic differences between the poor and good outcome

SUBMITTER: Wang T 

PROVIDER: S-EPMC10651953 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature