Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex.

ABSTRACT:

Aims

Transcranial focus ultrasound stimulation (tFUS) is a promising non-invasive neuromodulation technology. This study aimed to evaluate the modulatory effects of tFUS on human motor cortex (M1) excitability and explore the mechanism of neurotransmitter-related intracortical circuitry and plasticity.

Methods

Single pulse transcranial magnetic stimulation (TMS)-eliciting motor-evoked potentials (MEPs) were used to assessed M1 excitability in 10 subjects. Paired-pulse TMS was used to measure the effects of tFUS on GABA- and glutamate-related intracortical excitability and ¹ H-MRS was used to assess the effects of repetitive tFUS on GABA and Glx (glutamine + glutamate) neurometabolic concentrations in the targeting region in nine subjects.

Results

The etFUS

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10651987 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature