Photobiomodulation reduces neuropathic pain after spinal cord injury by downregulating CXCL10 expression.

ABSTRACT:

Background

Many studies have recently highlighted the role of photobiomodulation (PBM) in neuropathic pain (NP) relief after spinal cord injury (SCI), suggesting that it may be an effective way to relieve NP after SCI. However, the underlying mechanisms remain unclear. This study aimed to determine the potential mechanisms of PBM in NP relief after SCI.

Methods

We performed systematic observations and investigated the mechanism of PBM intervention in NP in rats after SCI. Using transcriptome sequencing, we screened CXCL10 as a possible target molecule for PBM intervention and validated the results in rat tissues using reverse transcription-polymerase chain reaction and western blotting. Using immunofluorescence co-labeling, astrocytes and microglia were identified as the cel

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10651991 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature