The mutations on the envelope glycoprotein D contribute to the enhanced neurotropism of the pseudorabies virus variant.

ABSTRACT: The pseudorabies virus (PRV) TJ strain, a variant of PRV, induces more severe neurological symptoms and higher mortality in piglets and mice than the PRV SC strain isolated in 1980. However, the mechanism underlying responsible for the discrepancy in virulence between these strains remains unclear. Our study investigated the differences in neurotropism between PRV TJ and PRV SC using both in vitro and in vivo models. We discovered that PRV TJ enters neural cells more efficiently than PRV SC. Furthermore, we found that PRV TJ has indistinguishable genomic DNA replication capability and axonal retrograde transport dynamics compared to the PRV SC. To gain deeper insights into the mechanisms underlying these differences, we constructed gene-interchanged chimeric virus constructs and assessed t

SUBMITTER: Wu H 

PROVIDER: S-EPMC10652121 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature