Pan-cancer mutational signature surveys correlated mutational signature with geospatial environmental exposures and viral infections.

ABSTRACT:

Background

Cancer has been disproportionally affecting minorities. Genomic-based cancer disparity analyses have been less common than conventional epidemiological studies. In the past decade, mutational signatures have been established as characteristic footprints of endogenous or exogenous carcinogens.

Methods

Integrating datasets of diverse cancer types from The Cancer Genome Atlas and geospatial environmental risks of the registry hospitals from the United States Environmental Protection Agency, we explored mutational signatures from the aspect of racial disparity concerning pollutant exposures. The raw geospatial environmental exposure data were refined to 449 air pollutants archived and modeled from 2007 to 2017 and aggregated to the census county level. Additionally, h

SUBMITTER: Bai J 

PROVIDER: S-EPMC10652135 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature