Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury.

ABSTRACT: Traumatic brain injury (TBI) is known to cause widespread neural disruption in the cerebrum. However, less is known about the association of TBI with cerebellar structure and how such changes may alter executive functioning. To investigate alterations in subregional cerebellum volume and cerebral white matter microstructure after pediatric TBI and examine subsequent changes in executive function. This retrospective cohort study combined 12 data sets (collected between 2006 and 2020) from 9 sites in the Enhancing Neuroimaging Genetics Through Meta-Analysis Consortium Pediatric TBI working group in a mega-analysis of cerebellar structure. Participants with TBI or healthy controls (some with orthopedic injury) were recruited from trauma centers, clinics, and institutional trauma registries, s

SUBMITTER: Keleher F 

PROVIDER: S-EPMC10652147 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature