CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm.

ABSTRACT: Introduction: Sperm motility, including chemotactic behavior, is regulated by changes in the intracellular Ca²⁺ concentration, and the sperm-specific Ca²⁺ channel CatSper has been shown to play an important role in the regulation of intracellular Ca²⁺. In particular, in mammals, CatSper is the only functional Ca²⁺ channel in the sperm, and mice deficient in the genes comprising the pore region of the Ca²⁺ channel are infertile due to the inhibition of sperm hyperactivation. CatSper is also thought to be involved in sea urchin chemotaxis. In contrast, in ascidian Ciona intestinalis, SAAF, a sperm attractant, interacts with Ca²⁺/ATPase, a Ca²⁺ pump. Although the existence of CatSper genes has be

SUBMITTER: Kijima T 

PROVIDER: S-EPMC10652287 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature