Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex-dependent manner.

ABSTRACT: Iron imbalance in the brain negatively affects brain function. With aging, iron levels increase in the brain and contribute to brain damage and neurological disorders. Changes in the cerebral vasculature with aging may enhance iron entry into the brain parenchyma, leading to iron overload and its deleterious consequences. Endothelial senescence has emerged as an important contributor to age-related changes in the cerebral vasculature. Evidence indicates that iron overload may induce senescence in cultured cell lines. Importantly, cells derived from female human and mice generally show enhanced senescence-associated phenotype, compared with males. Thus, we hypothesize that cerebral endothelial cells (CEC) derived from aged female mice are more susceptible to iron-induced senescence, compare

SUBMITTER: Noh B 

PROVIDER: S-EPMC10652299 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature