Cellular and molecular evidence that synaptic Schwann cells contribute to aging of mouse neuromuscular junctions.

ABSTRACT: Age-induced degeneration of the neuromuscular junction (NMJ) is associated with motor dysfunction and muscle atrophy. While the impact of aging on the NMJ presynapse and postsynapse is well-documented, little is known about the changes perisynaptic Schwann cells (PSCs), the synaptic glia of the NMJ, undergo during aging. Here, we examined PSCs in young, middle-aged, and old mice in three muscles with different susceptibility to aging. Using light and electron microscopy, we found that PSCs acquire age-associated cellular features either prior to or at the same time as the onset of NMJ degeneration. Notably, we found that aged PSCs fail to completely cap the NMJ even though they are more abundant in old compared with young mice. We also found that aging PSCs form processes that either intru

SUBMITTER: Hastings RL 

PROVIDER: S-EPMC10652323 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature