MicroRNAs-mediated regulation of insulin signaling in white adipose tissue during aging: Role of caloric restriction.

ABSTRACT: Caloric restriction is a non-pharmacological intervention known to ameliorate the metabolic defects associated with aging, including insulin resistance. The levels of miRNA expression may represent a predictive tool for aging-related alterations. In order to investigate the role of miRNAs underlying insulin resistance in adipose tissue during the early stages of aging, 3- and 12-month-old male animals fed ad libitum, and 12-month-old male animals fed with a 20% caloric restricted diet were used. In this work we demonstrate that specific miRNAs may contribute to the impaired insulin-stimulated glucose metabolism specifically in the subcutaneous white adipose tissue, through the regulation of target genes implicated in the insulin signaling cascade. Moreover, the expression of these miRNAs i

SUBMITTER: Corrales P 

PROVIDER: S-EPMC10652342 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature