In need of age-appropriate cardiac models: Impact of cell age on extracellular matrix therapy outcomes.

ABSTRACT: Aging is the main risk factor for cardiovascular disease (CVD). As the world's population ages rapidly and CVD rates rise, there is a growing need for physiologically relevant models of aging hearts to better understand cardiac aging. Translational research relies heavily on young animal models; however, these models correspond to early ages in human life, therefore cannot fully capture the pathophysiology of age-related CVD. Here, we first investigated the transcriptomic and proteomic changes that occur with human cardiac aging. We then chronologically aged human induced pluripotent stem cell-derived cardiomyocytes (iCMs) and showed that 14-month-old iCMs exhibited a similar aging profile to the human CMs and recapitulated age-related disease hallmarks. Using aged iCMs, we studied the eff

SUBMITTER: Ozcebe SG 

PROVIDER: S-EPMC10652343 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature