Common autoimmune diseases and urticaria: the causal relationship from a bidirectional two-sample mendelian randomization study.

ABSTRACT:

Objective

The immune response assumes a pivotal role in the underlying mechanisms of urticaria pathogenesis. The present study delves into an investigation of the genetic causal connections between urticaria and prevalent autoimmune afflictions, notably rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), ulcerative colitis (UC), and Crohn's disease (CD).

Methods

A bidirectional two-sample Mendelian randomization (MR) analysis was conducted to investigate the causal relationships involving four autoimmune diseases and urticaria. The genome-wide association study (GWAS) summary data of four autoimmune disease were sourced from the IEU OpenGWAS database. The GWAS summary data for urticaria were derived from the Finnish consortium dataset. The principal analytical app

SUBMITTER: Yang M 

PROVIDER: S-EPMC10652397 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature