Genetic profile of Chinese patients with small bowel cancer categorized by anatomic location.

ABSTRACT:

Background

Small bowel cancer (SBC) is a very rare solid malignancy. Consequently, compared with other malignant gastrointestinal tumors, our knowledge regarding SBC, specifically its molecular attributes, remains limited. Herein, we aim to provide an overview of the gene characteristics of Chinese patients with SBC, We particularly focus on elucidating the genetic intricacies that differentiate SBC patients whose primary tumors originate in distinct anatomical regions within the small bowel.

Methods

During the period ranging from February 2018 to December 2022, a total of 298 tumor samples were consecutively collected from Chinese patients diagnosed with small bowel cancer.. Next-generation sequencing (NGS) was performed to detect gene mutation, assess microsatellite instab

SUBMITTER: Shi C 

PROVIDER: S-EPMC10652443 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature