Integrating scRNA-seq to explore novel macrophage infiltration-associated biomarkers for diagnosis of heart failure.

ABSTRACT:

Objective

Inflammation and immune cells are closely intertwined mechanisms that contribute to the progression of heart failure (HF). Nonetheless, there is a paucity of information regarding the distinct features of dysregulated immune cells and efficient diagnostic biomarkers linked with HF. This study aims to explore diagnostic biomarkers related to immune cells in HF to gain new insights into the underlying molecular mechanisms of HF and to provide novel perspectives for the detection and treatment of HF.

Method

The CIBERSORT method was employed to quantify 22 types of immune cells in HF and normal subjects from publicly available GEO databases (GSE3586, GSE42955, GSE57338, and GSE79962). Machine learning methods were utilized to screen for important cell types. Single-cel

SUBMITTER: Li S 

PROVIDER: S-EPMC10652463 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature