Exploring the key genomic variation in monkeypox virus during the 2022 outbreak.

ABSTRACT:

Background

In 2022, a global outbreak of monkeypox occurred with a significant shift in its epidemiological characteristics. The monkeypox virus (MPXV) belongs to the B.1 lineage, and its genomic variations that were linked to the outbreak were investigated in this study. Previous studies have suggested that viral genomic variation plays a crucial role in the pathogenicity and transmissibility of viruses. Therefore, understanding the genomic variation of MPXV is crucial for controlling future outbreaks.

Methods

This study employed bioinformatics and phylogenetic approaches to evaluate the key genomic variation in the B.1 lineage of MPXV. A total of 979 MPXV strains were screened, and 212 representative strains were analyzed to identify specific substitutions in the viral gen

SUBMITTER: Zhu J 

PROVIDER: S-EPMC10652487 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature