Hyperthermia elevates brain temperature and improves behavioural signs in animal models of autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorders (ASD) are predominantly neurodevelopmental and largely genetically determined. However, there are human data supporting the idea that fever can improve symptoms in some individuals, but those data are limited and there are almost no data to support this from animal models. We aimed to test the hypothesis that elevated body temperature would improve function in two animal models of ASD.

Methods

We used a 4 h whole-body hyperthermia (WBH) protocol and, separately, systemic inflammation induced by bacterial endotoxin (LPS) at 250 µg/kg, to dissociate temperature and inflammatory elements of fever in two ASD animal models: C58/J and Shank3B- mice. We used one- or two-way ANOVA and t-tests with normally distributed data and Kruskal-Wallis or M

SUBMITTER: Lopez-Rodriguez AB 

PROVIDER: S-EPMC10652497 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature