What exactly does the PfK13 C580Y mutation in Plasmodium falciparum influence?

ABSTRACT:

Background

The emergence and spread of artemisinin resistance threaten global malaria control and elimination goals, and encourage research on the mechanisms of drug resistance in malaria parasites. Mutations in Plasmodium falciparum Kelch 13 (PfK13) protein are associated with artemisinin resistance, but the unique or common mechanism which results in this resistance is unclear.

Methods

We analyzed the effects of the PfK13 mutation on the transcriptome and proteome of P. falciparum at different developmental stages. Additionally, the number of merozoites, hemozoin amount, and growth of P. falciparum 3D7^C580Y and P. falciparum 3D7^WT were compared. The impact of iron supplementation on the number of merozoites of P. falciparum 3D7^C580Y was als

SUBMITTER: Si W 

PROVIDER: S-EPMC10652512 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature