Changes in ADAR RNA editing patterns in CMV and ZIKV congenital infections.

ABSTRACT:

Background

RNA editing is a process that increases transcriptome diversity, often through Adenosine Deaminases Acting on RNA (ADARs) that catalyze the deamination of adenosine to inosine. ADAR editing plays an important role in regulating brain function and immune activation, and is dynamically regulated during brain development. Additionally, the ADAR1 p150 isoform is induced by interferons in viral infection and plays a role in antiviral immune response. However, the question of how virus-induced ADAR expression affects host transcriptome editing remains largely unanswered. This question is particularly relevant in the context of congenital infections, given the dynamic regulation of ADAR editing during brain development, the importance of this editing for brain function, and sub

SUBMITTER: Wales-McGrath B 

PROVIDER: S-EPMC10652522 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature