Role of monocytes and dendritic cells in cardiac reverse remodelling after cardiac resynchronization therapy.

ABSTRACT:

Background and aims

Monocytes and dendritic cells (DC) are both key inflammatory cells, with recognized effects on cardiac repair. However, there are distinct subsets of monocytes with potential for beneficial or detrimental effects on heart failure (HF) pathogenesis. The connection between reverse cardiac remodelling, the potential anti-inflammatory effect of cardiac resynchronization therapy (CRT) and monocytes and DC homeostasis in HF is far from being understood. We hypothesized that monocytes and DC play an important role in cardiac reverse remodelling and CRT response. Therefore, we aimed to assess the potential role of baseline peripheral levels of blood monocytes and DC subsets and their phenotypic and functional activity for CRT response, in HF patients. As a secondary obj

SUBMITTER: Martins S 

PROVIDER: S-EPMC10652525 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature