Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease.

ABSTRACT:

Background

Metabolite signatures of long-term alcohol consumption are lacking. To better understand the molecular basis linking alcohol drinking and cardiovascular disease (CVD), we investigated circulating metabolites associated with long-term alcohol consumption and examined whether these metabolites were associated with incident CVD.

Methods

Cumulative average alcohol consumption (g/day) was derived from the total consumption of beer, wine, and liquor on average of 19 years in 2428 Framingham Heart Study Offspring participants (mean age 56 years, 52% women). We used linear mixed models to investigate the associations of alcohol consumption with 211 log-transformed plasma metabolites, adjusting for age, sex, batch, smoking, diet, physical activity, BMI, and familial relati

SUBMITTER: Li Y 

PROVIDER: S-EPMC10652547 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature