Causal association between body mass index and autoimmune thyroiditis: evidence from Mendelian randomization.

ABSTRACT:

Background

Recent studies have reported associations between body mass index (BMI) and various autoimmune disorders. However, it is still uncertain whether there exists a direct cause-and-effect relationship between BMI and autoimmune thyroiditis (AIT). The aim of our study is to investigate the causal association between BMI and AIT.

Methods

We conducted a two-sample summary data Mendelian randomization (MR) analysis using genome-wide association studies (GWAS) summary statistics data related to BMI as exposure, and GWAS summary statistic data sets for AIT as the outcome. Robustly associated single-nucleotide polymorphisms (SNPs) for BMI were selected as instrumental variables (IVs). We used the inverse variance weighted (IVW) method as the primary method and performed othe

SUBMITTER: Huo J 

PROVIDER: S-EPMC10652572 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature