Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor.

ABSTRACT:

Background

Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility, and stimulation of endocrine and exocrine gland secretion. Their abnormal expression has been reported to be associated with neurological disorders, inflammation, and cancer. Even though NKs are expressed in the same cells with their expression being inversely correlated in some conditions, there is no direct evidence to prove their interaction. Understanding the functional crosstalk between NKs in mediated downstream signaling and cellular responses may elucidate the roles of each receptor in pathophysiology.

Results

In thi

SUBMITTER: Nguyen LP 

PROVIDER: S-EPMC10652611 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature