Long-term humoral and cellular immunity after primary SARS-CoV-2 infection: a 20-month longitudinal study.

ABSTRACT:

Background

SARS-CoV-2 remains a world-wide health issue. SARS-CoV-2-specific immunity is induced upon both infection and vaccination. However, defining the long-term immune trajectory, especially after infection, is limited. In this study, we aimed to further the understanding of long-term SARS-CoV-2-specific immune response after infection.

Results

We conducted a longitudinal cohort study among 93 SARS-CoV-2 recovered individuals. Immune responses were continuously monitored for up to 20 months after infection. The humoral responses were quantified by Spike- and Nucleocapsid-specific IgG levels. T cell responses to Spike- and non-Spike epitopes were examined using both intercellular cytokine staining (ICS) assay and Activation-Induced marker (AIM) assay with quantification

SUBMITTER: Hvidt AK 

PROVIDER: S-EPMC10652616 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature