Mathematical modeling and application of IL-1β/TNF signaling pathway in regulating chondrocyte apoptosis.

ABSTRACT: Introduction: Mathematical model can be used to model complex biological processes, and have shown potential in describing apoptosis in chondrocytes. Method: In order to investigate the regulatory mechanisms of TNF signaling pathway in regulating chondrocyte apoptosis, a fractional-order differential equation model is proposed to describe the dynamic behavior and mutual interaction of apoptosis-related genes under the activation of TNF signaling pathway. Compared with the traditional molecular biology techniques, the proposed mathematical modeling has advantages to providing a more comprehensive understanding of the regulatory mechanisms of TNF signaling pathway in chondrocyte apoptosis. Result: In this paper, differentially expressed genes induced by IL-1β in human ch

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10652750 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature