Hindbrain rhombomere centers harbor a heterogenous population of dividing progenitors which rely on Notch signaling.

ABSTRACT: Tissue growth and morphogenesis are interrelated processes, whose tight coordination is essential for the production of different cell fates and the timely precise allocation of stem cell capacities. The zebrafish embryonic brainstem, the hindbrain, exemplifies such coupling between spatiotemporal cell diversity acquisition and tissue growth as the neurogenic commitment is differentially distributed over time. Here, we combined cell lineage and in vivo imaging approaches to reveal the emergence of specific cell population properties within the rhombomeres. We studied the molecular identity of hindbrain rhombomere centers and showed that they harbor different progenitor capacities that change over time. By clonal analysis, we revealed that cells within the center of rhombomeres decre

SUBMITTER: Belmonte-Mateos C 

PROVIDER: S-EPMC10652760 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature