Natural biomass-derived carbon dots as a potent solubilizer with high biocompatibility and enhanced antioxidant activity.

ABSTRACT: Numerous natural compounds exhibit low bioavailability due to suboptimal water solubility. The solubilization methods of the modern pharmaceutical industry in contemporary pharmaceutical research are restricted by low efficiency, sophisticated technological requirements, and latent adverse effects. There is a pressing need to elucidate and implement a novel solubilizer to ameliorate these challenges. This study identified natural biomass-derived carbon dots as a promising candidate. We report on natural fluorescent carbon dots derived from Aurantia Fructus Immatures (AFI-CDs), which have exhibited a remarkable solubilization effect, augmenting naringin (NA) solubility by a factor of 216.72. Subsequent analyses suggest that the solubilization mechanism is potentially contingent upon

SUBMITTER: Wu T 

PROVIDER: S-EPMC10652762 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature