Predictive factors of response to infliximab therapy in Brazilian inflammatory bowel disease patients.

ABSTRACT:

Background

Biological therapies have revolutionized the treatment of patients with inflammatory bowel disease (IBD). Infliximab (IFX) has been shown to be effective in inducing and maintaining remission in patients with Crohn's disease and ulcerative colitis. However, about one-third of the patients are primary non-responders, and up to half can lose response over time. Hence, it is important to assess which factors are related to treatment failure.

Objectives

We aimed to identify factors predicting clinical and endoscopic remission with IFX treatment during maintenance therapy in a Brazilian IBD referral center.

Design

We conducted a cross-sectional study to describe demographic, clinical, and IBD therapy-related characteristics of IBD patients treated with IFX for a

SUBMITTER: Martins CA 

PROVIDER: S-EPMC10652804 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature