Anti-Helicobacter pylori Activity of Six Major Compounds Isolated from Rumex acetosa.

ABSTRACT: Gastric problems are often caused by the well-known Helicobacter pylori (H. pylori) bacterium. One of the biggest obstacles to the treatment of H. pylori infections is increasing the antibiotic resistance. During our search for naturally derived anti-H. pylori compounds, six major compounds were isolated from the methylene chloride (CH₂Cl₂) and ethyl acetate (EtOAc) fractions of Rumex acetosa that showed anti-H. pylori activity. Three anthraquinones and three anthraquinone glucosides were identified as the major chemical constituents of the CH₂Cl₂ and EtOAc fractions, respectively. The chemical structures were identified to be emodin (1), chrysophanol (2), physcion (3), emodin-8-O<

SUBMITTER: Kang DM 

PROVIDER: S-EPMC10652819 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature