Bhlhe40 limits early IL-10 production from CD4⁺ T cells during Plasmodium yoelii 17X infection.

ABSTRACT: The cytokine IL-10 suppresses T-cell-mediated immunity, which is required to control infection with Plasmodium yoelii. Consequently, IL-10 can delay the time needed to resolve this infection, leading to a higher parasite burden. While the pathways that lead to IL-10 production by CD4⁺ T cells are well defined, much less is known about the mediators that suppress the expression of this potent anti-inflammatory cytokine. Here, we show that the transcription factor basic helix-loop-helix family member e40 (Bhlhe40) contributes to controlling parasite burden in response to P. yoelii infection in mice. Loss of Bhlhe40 expression in mice results in higher Il10 expression, higher peak parasitemia, and a delay in parasite clearance. The observed phenotype was not du

SUBMITTER: O'Neal KA 

PROVIDER: S-EPMC10652903 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature