Legionella pneumophila inhibits type I interferon signaling to avoid cell-intrinsic host cell defense.
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ABSTRACT:
SUBMITTER: Allen CNS
PROVIDER: S-EPMC10652965 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
<i>Legionella pneumophila</i> inhibits type I interferon signaling to avoid cell-intrinsic host cell defense.
Allen Charles N S CNS Banks Dallas A DA Shuster Michael M Vogel Stefanie N SN O'Connor Tamara J TJ Briken Volker V
Infection and immunity 20231016 11
The host type I interferon (IFN) response protects against <i>Legionella pneumophila</i> infections. Other bacterial pathogens inhibit type I IFN-mediated cell signaling; however, the interaction between this signaling pathway and <i>L. pneumophila</i> has not been well described. Here, we demonstrate that <i>L. pneumophila</i> inhibits the IFN-β signaling pathway but does not inhibit IFN-γ-mediated cell signaling. The addition of IFN-β to <i>L. pneumophila</i>-infected macrophages limited bacte ...[more]
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